2144777-92-2

2144777-92-2 structure

Name: Azido-PEG5-CH2CO2-PFP
Chemical Name: Azido-PEG5-CH2CO2-PFP
CAS Number: 2144777-92-2
Molecular Formula: C₁₈H₂₂F₅N₃O₇
Molecular Weight: 487.38
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-20 16:01:02
Modify Date: 2025-10-08 19:51:05
Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Azido-PEG5-CH2CO2-PFP

Description	Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.