Gefitinib impurity 1

Modify Date: 2024-01-03 19:12:37

Gefitinib impurity 1 structure	Common Name	Gefitinib impurity 1
	CAS Number	675126-26-8	Molecular Weight	321.328
	Density	1.3±0.1 g/cm3	Boiling Point	522.3±50.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₉N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	269.7±30.1 °C

Use of Gefitinib impurity 1

Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Name	4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile
Synonym	More Synonyms

Description	Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Density	1.3±0.1 g/cm3
Boiling Point	522.3±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₉N₃O₅
Molecular Weight	321.328
Flash Point	269.7±30.1 °C
Exact Mass	321.132477
PSA	100.54000
LogP	1.50
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.570

Hazard Codes	Xi

3-(3-Morpholiny...

CAS#:675126-28-0

~96%

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

4-methoxy-6-nit...

CAS#:861453-13-6

Gefitinib impurity 1

CAS#:675126-26-8

Literature: WO2005/70909 A1, ; Page/Page column 25-26 ;

4-(3-Chloroprop...

CAS#:7357-67-7

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Heterocycles, , vol. 71, # 1 p. 39 - 48

Isovanillin

CAS#:621-59-0

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Heterocycles, , vol. 71, # 1 p. 39 - 48

3-Hydroxy-4-met...

CAS#:52805-46-6

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106

4-methoxy-3-[3-...

CAS#:934191-95-4

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Heterocycles, , vol. 71, # 1 p. 39 - 48

4-Methoxy-3-[3-...

CAS#:861453-11-4

Gefitinib impurity 1

CAS#:675126-26-8

Literature: Heterocycles, , vol. 71, # 1 p. 39 - 48

Precursor 6
CAS#:675126-28-0 3-(3-Morpholiny... CAS#:861453-13-6 4-methoxy-6-nit... CAS#:7357-67-7 4-(3-Chloroprop... CAS#:621-59-0 Isovanillin
CAS#:52805-46-6 3-Hydroxy-4-met... CAS#:861453-11-4 4-Methoxy-3-[3-...
DownStream 5
CAS#:246512-44-7 Gefitinib impurity 2 CAS#:847949-49-9 O-Desmethyl gef... CAS#:675126-27-9 2-amino-4-metho... CAS#:184475-35-2 Gefitinib
CAS#:199327-61-2 Gefitinib impurity 5