246512-44-7
246512-44-7 structure
- Name: Gefitinib impurity 2
- Chemical Name: 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzamide
- CAS Number: 246512-44-7
- Molecular Formula: C15H23N3O4
- Molecular Weight: 309.36100
- Catalog: Research Areas Others
- Create Date: 2018-12-30 20:04:10
- Modify Date: 2024-01-02 10:40:10
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Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
| Name | 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzamide |
|---|---|
| Synonyms | 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide |
| Description | Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. |
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| Related Catalog | |
| References |
| Molecular Formula | C15H23N3O4 |
|---|---|
| Molecular Weight | 309.36100 |
| Exact Mass | 309.16900 |
| PSA | 101.03000 |
| LogP | 1.88070 |
| Precursor 7 | |
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| DownStream 3 | |
