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675126-26-8

675126-26-8 structure
675126-26-8 structure
  • Name: Gefitinib impurity 1
  • Chemical Name: 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile
  • CAS Number: 675126-26-8
  • Molecular Formula: C15H19N3O5
  • Molecular Weight: 321.328
  • Catalog: Research Areas Others
  • Create Date: 2018-12-28 18:59:05
  • Modify Date: 2025-08-20 10:42:24
  • Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Name 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile
Synonyms Benzonitrile, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-
y6567
4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile
4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-
Description Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog
References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.
Density 1.3±0.1 g/cm3
Boiling Point 522.3±50.0 °C at 760 mmHg
Molecular Formula C15H19N3O5
Molecular Weight 321.328
Flash Point 269.7±30.1 °C
Exact Mass 321.132477
PSA 100.54000
LogP 1.50
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.570
Hazard Codes Xi
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title: CAS No. 675126-26-8 | Chemsrc address: https://www.chemsrc.com/en/baike/223952.html

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