Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-methoxy-5-[3-(morpholin-4-yl)propoxy]-2- nitro benzonitrile (GFT-III)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

675126-26-8

675126-26-8 structure

Name: Gefitinib impurity 1
Chemical Name: 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile
CAS Number: 675126-26-8
Molecular Formula: C₁₅H₁₉N₃O₅
Molecular Weight: 321.328
Catalog: Research Areas Others
Create Date: 2018-12-28 18:59:05
Modify Date: 2024-01-03 19:12:37
Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Name	4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile
Synonyms	Benzonitrile, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro- y6567 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-

Description	Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.