Gefitinib impurity 2

Modify Date: 2025-08-27 11:52:08

Gefitinib impurity 2 structure	Common Name	Gefitinib impurity 2
	CAS Number	246512-44-7	Molecular Weight	309.36100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₃N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Gefitinib impurity 2

Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Name	2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzamide
Synonym	More Synonyms

Description	Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

[2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

Molecular Formula	C₁₅H₂₃N₃O₄
Molecular Weight	309.36100
Exact Mass	309.16900
PSA	101.03000
LogP	1.88070

2-amino-4-metho...

CAS#:675126-27-9

~37%

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

4-Methoxy-5-(3-...

CAS#:861453-16-9

Gefitinib impurity 2

CAS#:246512-44-7

Literature: NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; PULLA REDDY, Muddasani; NAGESHWARA RAO, Bollepalli; VENKAIAH CHOWDARY, Nannapaneni Patent: WO2005/70909 A1, 2005 ; Location in patent: Page/Page column 29 ;

4-(3-Chloroprop...

CAS#:7357-67-7

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

3-(3-Morpholiny...

CAS#:675126-28-0

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

Gefitinib impurity 1

CAS#:675126-26-8

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

Isovanillin

CAS#:621-59-0

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

3-Hydroxy-4-met...

CAS#:52805-46-6

Gefitinib impurity 2

CAS#:246512-44-7

Literature: Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106

Precursor 7
CAS#:675126-27-9 2-amino-4-metho... CAS#:861453-16-9 4-Methoxy-5-(3-... CAS#:7357-67-7 4-(3-Chloroprop... CAS#:675126-28-0 3-(3-Morpholiny...
CAS#:675126-26-8 Gefitinib impurity 1 CAS#:621-59-0 Isovanillin CAS#:52805-46-6 3-Hydroxy-4-met...
DownStream 3
CAS#:847949-49-9 O-Desmethyl gef... CAS#:184475-35-2 Gefitinib CAS#:199327-61-2 Gefitinib impurity 5

2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide

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Gefitinib impurity 2

Use of Gefitinib impurity 2

Names

Gefitinib impurity 2 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.