O-Desmethyl gefitinib
Modify Date: 2025-08-24 13:21:56
O-Desmethyl gefitinib structure
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Common Name | O-Desmethyl gefitinib | ||
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| CAS Number | 847949-49-9 | Molecular Weight | 432.87600 | |
| Density | 1.386g/cm3 | Boiling Point | 606.4ºC at 760 mmHg | |
| Molecular Formula | C21H22ClFN4O3 | Melting Point | 117-120ºC | |
| MSDS | N/A | Flash Point | 320.5ºC | |
Use of O-Desmethyl gefitinibO-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2]. |
| Name | 4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-7-one |
|---|---|
| Synonym | More Synonyms |
| Description | O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2]. |
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| Related Catalog | |
| Target |
IC50: 36 nM (EGFR)[2] |
| References |
| Density | 1.386g/cm3 |
|---|---|
| Boiling Point | 606.4ºC at 760 mmHg |
| Melting Point | 117-120ºC |
| Molecular Formula | C21H22ClFN4O3 |
| Molecular Weight | 432.87600 |
| Flash Point | 320.5ºC |
| Exact Mass | 432.13600 |
| PSA | 79.74000 |
| LogP | 3.98350 |
| Index of Refraction | 1.65 |
| HS Code | 2934999090 |
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| Precursor 9 | |
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| DownStream 0 | |
CAS#:184475-35-2
CAS#:199327-61-2
CAS#:7357-67-7
CAS#:675126-28-0
CAS#:675126-27-9
CAS#:675126-26-8
CAS#:246512-44-7
CAS#:621-59-0
CAS#:52805-46-6| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 7-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy] |
| O-Desmethyl Gefitinib |
| O-Demethyl-Gefitinib |
| 4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol |
| 4-(3'-chloro-4'-fluoroanilino)-7-hydroxy-6-(3-morpholinopropoxy)quinazoline |
| Gefitinib Impurity 1 |