O-Desmethyl gefitinib

Modify Date: 2024-01-18 17:25:55

O-Desmethyl gefitinib structure	Common Name	O-Desmethyl gefitinib
	CAS Number	847949-49-9	Molecular Weight	432.87600
	Density	1.386g/cm3	Boiling Point	606.4ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₂ClFN₄O₃	Melting Point	117-120ºC
	MSDS	N/A	Flash Point	320.5ºC

Use of O-Desmethyl gefitinib

O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

Name	4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-7-one
Synonym	More Synonyms

Description	O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 36 nM (EGFR)[2]
References	[1]. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57. [2]. McKillop D, et al. Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica. 2006 Jan;36(1):29-39.

Density	1.386g/cm3
Boiling Point	606.4ºC at 760 mmHg
Melting Point	117-120ºC
Molecular Formula	C₂₁H₂₂ClFN₄O₃
Molecular Weight	432.87600
Flash Point	320.5ºC
Exact Mass	432.13600
PSA	79.74000
LogP	3.98350
Index of Refraction	1.65

HS Code	2934999090

Precursor 9
CAS#:184475-35-2 Gefitinib CAS#:199327-61-2 Gefitinib impurity 5 CAS#:7357-67-7 4-(3-Chloroprop... CAS#:675126-28-0 3-(3-Morpholiny...
CAS#:675126-27-9 2-amino-4-metho... CAS#:675126-26-8 Gefitinib impurity 1 CAS#:246512-44-7 Gefitinib impurity 2 CAS#:621-59-0 Isovanillin
CAS#:52805-46-6 3-Hydroxy-4-met...
DownStream 0