503612-76-8

503612-76-8 structure

Name: O-Desmethyl apixaban
Chemical Name: 1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number: 503612-76-8
Molecular Formula: C₂₄H₂₃N₅O₄
Molecular Weight: 445.47100
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-10-11 22:39:45
Modify Date: 2024-02-06 19:37:52
O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2].

Name	1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
Synonyms	4-Demethoxy-4-hydroxy Apixaban O-demethyl-apixaban Apixaban Impurity 18

Description	O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Pinto DJ, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2007 Nov 1;50(22):5339-56. [2]. Raghavan N, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos. 2009 Jan;37(1):74-81.

Molecular Formula	C₂₄H₂₃N₅O₄
Molecular Weight	445.47100
Exact Mass	445.17500
PSA	122.75000
LogP	3.41080

503612-72-4

~6%

503612-76-8

Literature: Pinto, Donald J.P.; Quan, Mimi L.; Orwat, Michael J.; Li, Yun-Long; Han, Wei; Qiao, Jennifer X.; Lam, Patrick Y.S.; Koch, Stephanie L. Patent: US2003/191115 A1, 2003 ;

Precursor 1
503612-72-4
DownStream 0

503612-76-8	586357-02-0
186377-56-0	740816-86-8
847949-49-9	70877-75-7
150131-21-8	1322681-36-6
1187545-62-5	1630732-39-6