O-Desmethyl apixaban
Modify Date: 2024-02-06 19:37:52
O-Desmethyl apixaban structure
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Common Name | O-Desmethyl apixaban | ||
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| CAS Number | 503612-76-8 | Molecular Weight | 445.47100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H23N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of O-Desmethyl apixabanO-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. |
| Name | 1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide |
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| Synonym | More Synonyms |
| Description | O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. |
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| Related Catalog | |
| References |
| Molecular Formula | C24H23N5O4 |
|---|---|
| Molecular Weight | 445.47100 |
| Exact Mass | 445.17500 |
| PSA | 122.75000 |
| LogP | 3.41080 |
|
~6%
O-Desmethyl apixaban CAS#:503612-76-8 |
| Literature: Pinto, Donald J.P.; Quan, Mimi L.; Orwat, Michael J.; Li, Yun-Long; Han, Wei; Qiao, Jennifer X.; Lam, Patrick Y.S.; Koch, Stephanie L. Patent: US2003/191115 A1, 2003 ; |
![ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate structure](https://www.chemsrc.com/caspic/424/503612-72-4.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| 4-Demethoxy-4-hydroxy Apixaban |
| O-demethyl-apixaban |
| Apixaban Impurity 18 |