Gefitinib N-oxide

Modify Date: 2024-02-13 18:29:00

Gefitinib N-oxide structure	Common Name	Gefitinib N-oxide
	CAS Number	847949-51-3	Molecular Weight	462.90200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄ClFN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Gefitinib N-oxide

Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

Name	N-(3-chloro-4-fluorophenyl)-[7-methoxy-6-(3-(4-(1-oxymorpholinyl))propoxy)-4-quinazolin]amine
Synonym	More Synonyms

Description	Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]
References	[1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.

Molecular Formula	C₂₂H₂₄ClFN₄O₄
Molecular Weight	462.90200
Exact Mass	462.14700
PSA	94.93000
LogP	4.32000

Gefitinib Morpholine N-oxide

Gefitinib N-Oxide

gefitinib N-oxide

Gefitinib Impurity 13

DC Chemicals Limited
China
Product Name: Gefitinib N-oxide
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Gefitinib N-oxide

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