Gefitinib impurity 1

Names

[ Name ]:
Gefitinib impurity 1

[Synonym ]:
Benzonitrile, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-
y6567
4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile
4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-

Biological Activity

[Description]:

Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
522.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₉N₃O₅

[ Molecular Weight ]:
321.328

[ Flash Point ]:
269.7±30.1 °C

[ Exact Mass ]:
321.132477

[ PSA ]:
100.54000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.570

Safety Information

[ Hazard Codes ]:
Xi

Gefitinib impurity 1

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds