Gefitinib impurity 5

Names

[ CAS No. ]:
199327-61-2

[ Name ]:
Gefitinib impurity 5

[Synonym ]:
4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]-
7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone
Gefitinib Impurity 17

Biological Activity

[Description]:

Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
564.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₁N₃O₄

[ Molecular Weight ]:
319.356

[ Flash Point ]:
295.2±30.1 °C

[ Exact Mass ]:
319.153198

[ PSA ]:
76.68000

[ LogP ]:
0.29

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.611

[ Storage condition ]:
2~8℃

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%