Ubiquinone Q0

Modify Date: 2024-01-02 15:14:16

Ubiquinone Q0 structure	Common Name	Ubiquinone Q0
	CAS Number	605-94-7	Molecular Weight	182.173
	Density	1.2±0.1 g/cm3	Boiling Point	331.4±42.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀O₄	Melting Point	58-60 °C(lit.)
	MSDS	Chinese USA	Flash Point	148.6±27.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of Ubiquinone Q0

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].

Name	ubiquinone-0
Synonym	More Synonyms

Description	Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease
In Vitro	Coenzyme Q0 (0-40 µM; 24 h) and inhibits viability and growth of human ovarian carcinoma cells[1]. Coenzyme Q0 (CoQ0) (0-30 µM; 24 h; SKOV-3 cells) has anti-proliferative activity through induction of G2/M cell-cycle arrest and reduction of cell-cycle regulatory proteins[1]. Coenzyme Q0 (CoQ0) (0-30 µM; 0-30 min; SKOV-3 cells) increases intracellular ROS levels to promote SKOV-3 cell death[1]. Coenzyme Q0 (CoQ0) (0-30 µM; 24 h; SKOV-3 cells) induces autophagy by increase accumulation of LC3-II, GFP-LC3 puncta, AVOs formation and Beclin-1/Bcl-2 dysregulation[1]. Coenzyme Q0 (CoQ0) (0-30 µM; 24 h; SKOV-3 cells) induces apoptosis by mitochondrial (caspase-3, PARP and Bax/Bcl-2 dysregulation) and ER stress (caspase-12 and Hsp70) signals[1]. Coenzyme Q0 (CoQ0) (30 µM; 24 h; SKOV-3 cells) suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms[1]. Coenzyme Q0 (CoQ0) (0-10 µM; 0.5-18 h; RAW264.7 cells) regulates NFκB/AP-1 activation and enhances Nrf2 stabilization[2]. Coenzyme Q0 (CoQ0) (5 µM; 0-12 h; EA.hy 926 cells) has anti-angiogenic activity in EA.hy 926 cells[3]. Cell Viability Assay[1] Cell Line: SKOV-3, A2780 and A2870/CP70 cells Concentration: 0, 10, 20, 30 and 40 µM Incubation Time: 24 hours Result: Decreased viability with the IC50 values of 26.6 µM, 27.3 µM and 28.4 µM for SKOV-3, A2780 and A2870/CP70 cells, respectively. Cell Cycle Analysis[1] Cell Line: SKOV-3, A2780 and A2870/CP70 cells Concentration: 0, 10, 20 and 30 µM Incubation Time: 24 hours Result: Arrested cell cycle at G2/M phase and reduced cell-cycle proteins in SKOV-3 cells. Apoptosis Analysis[1] Cell Line: SKOV-3, A2780 and A2870/CP70 cells Concentration: 0, 5, 15 and 30 µM Incubation Time: 24 hours Result: Promoted the conversion of LC3–1 to LC3-II and increased the LC3-II accumulation. Increased Bax/Bcl-2 ratio in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: SKOV-3 cells Concentration: 0, 10, 20 and 30 µM Incubation Time: 24 hours Result: Had the percentage of early apoptotic cells are 25.1%, 34% and 36% for 10, 20 and 30 µM, respectively. Western Blot Analysis[1] Cell Line: SKOV-3 cells Concentration: 0, 5, 15 and 30 µM Incubation Time: 24 hours Result: Activated of caspase-3 and cleavaged of PARP. Increased the expressions of caspase-12, HSP-70 and Bax in a dose-dependent manner, decreased the expressions of Bcl-2. Western Blot Analysis[1] Cell Line: SKOV-3 cells Concentration: 30 µM Incubation Time: 24 hours Result: Decreased the phosphorylated HER-2 (Y1221) levels, p-AKT (Ser473) and p-mTOR (S2448) levels. Western Blot Analysis[2] Cell Line: RAW264.7 cells Concentration: 0, 2.5, 5 and 10 µM Incubation Time: 0.5-18 hours Result: Inhibited iNOS/COX-2 protein expressions with reductions of NO, PGE2, TNF-α and IL-1β secretions. Western Blot Analysis[3] Cell Line: EA.hy 926 cells Concentration: 5 µM Incubation Time: 0, 1, 3, 6 and 12 hours Result: Increased expressions of heme oxygenase-1 (HO-1) and γ-glutamylcysteine synthetase (γ-GCLC), inhibits protein expressions of matrix metalloproteinase-9 (MMP-9), reduces TNF-α-induced nuclear translocation and transcriptional activation of nuclear factor-κB (NF-κB).
In Vivo	Coenzyme Q0 (CoQ0) (1.5 and 2.5 mg/kg; i.p.; once every four days, for 52 d) suppresses tumor growth in SKOV-3 xenografted nude mice[1]. Coenzyme Q0(CoQ0) (5 mg/kg; p.o.; for 4 h) has anti-inflammatory activities through Nrf2 activation and NFκB inhibition in liver and spleen of LPS-treated mice[2]. Animal Model: SKOV-3 xenografted nude mice[1] Dosage: 1.5 and 2.5 mg/kg Administration: Intraperitoneal injection; Once every four days, for 52 days Result: Inhibited the tumor growth at 1.5 and 2.5 mg/kg. Animal Model: LPS-treated female FVB mice[2] Dosage: 5 mg/kg Administration: Oral administration; for 4 hours Result: Down-regulates inflammatory genes in liver and spleen tissues of LPS injected mice.
References	[1]. Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859(2):246-61. [2]. Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859(2):246-61. [3]. Yang HL, et, al. Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells. Biochem Pharmacol. 2015 Nov 1;98(1):144-56.

Density	1.2±0.1 g/cm3
Boiling Point	331.4±42.0 °C at 760 mmHg
Melting Point	58-60 °C(lit.)
Molecular Formula	C₉H₁₀O₄
Molecular Weight	182.173
Flash Point	148.6±27.9 °C
Exact Mass	182.057907
PSA	52.60000
LogP	0.12
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.498
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents.

Ubiquinone Q0 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2

Precursor 8
CAS#:6443-69-2 1,2,3-Trimethox... CAS#:1128-32-1 2,3-dimethoxy-5... CAS#:39068-88-7 2,3,4-Trimethox... CAS#:494-99-5 1,2-Dimethoxy-4...
CAS#:3066-90-8 2,3-Dimethoxy-5... CAS#:35896-58-3 2,3,4,5-Tetrame... CAS#:1916-07-0 Trimethylgallic... CAS#:2103-57-3 2,3,4-Trimethox...
DownStream 10
CAS#:1065-31-2 Coenzyme Q6 CAS#:3066-90-8 2,3-Dimethoxy-5... CAS#:490-83-5 L-Dehydroascorb... CAS#:35896-58-3 2,3,4,5-Tetrame...
CAS#:303-95-7 ubiquinone-7 CAS#:303-98-0 coenzyme Q10 CAS#:73875-27-1 1-Bromo-2,3,4,5... CAS#:132080-64-9 9-(4,5-dimethox...
CAS#:34417-79-3 2-bromo-5,6-dim... CAS#:303-97-9 ubiquinone-9

Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.

J. Bacteriol. 197 , 2610-9, (2015)

Clostridium thermocellum and Thermoanaerobacterium saccharolyticum are thermophilic bacteria that have been engineered to produce ethanol from the cellulose and hemicellulose fractions of biomass, res...

Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.

J. Bioenerg. Biomembr. 44(1) , 207-12, (2012)

The permeability transition pore (PTP) is a mitochondrial inner membrane channel involved in cell death. The inhibition of PTP opening has been proved to be an effective strategy to prevent cell death...

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

PLoS ONE 5 , e11792, (2010)

Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by u...

1,2,3-Dimethoxy-5-methyl-1,4-benzoquinone

2,5-Cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-

EINECS 210-100-8

2,3-dimethoxy-5-methyl-1,4-benzoquinone

2,3-Dimethoxy-5-methylcyclohexa-2,5-dien-1,4-dion

p-Benzoquinone, 2,3-dimethoxy-5-methyl-

2,3-Dimethoxy-5-Methyl-p-Benzoquinone

Ubiquinone Q0

2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

MFCD00001595

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ubiquinone Q0
Price: ￥348.0/25g ￥118.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,3-Dimethoxy-5-methyl-p-benzoquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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