Bis-Tos-PEG6

Modify Date: 2025-08-27 13:00:06

Bis-Tos-PEG6 Structure
Bis-Tos-PEG6 structure
 Common Name Bis-Tos-PEG6
CAS Number 42749-27-9 Molecular Weight 590.70300
Density 1.24g/cm3 Boiling Point 687.4ºC at 760 mmHg
Molecular Formula C26H38O11S2 Melting Point N/A
MSDS Chinese USA Flash Point 369.5ºC

 Use of Bis-Tos-PEG6


Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Synonym More Synonyms

 Bis-Tos-PEG6 Biological Activity

Description Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.24g/cm3
Boiling Point 687.4ºC at 760 mmHg
Molecular Formula C26H38O11S2
Molecular Weight 590.70300
Flash Point 369.5ºC
Exact Mass 590.18600
PSA 149.65000
LogP 4.65880
Index of Refraction 1.525
InChIKey ZIZXHPCBPDNLDD-UHFFFAOYSA-N
SMILES Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1

 Safety Information

RIDADR NONH for all modes of transport
HS Code 2909499000

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

PEG7-bis-Tos
Hexaethylene glycol ditosylate
O,O'-ditosyl-3,6,9,12,15-pentaoxaheptadecane-1,17-diol
3,6,9,12,15-pentaoxaheptadecane-1,17-diol ditosylate
HEG ditosylate
3,6,9,12,15-pentaoxa-1,17-heptadecyl di-p-toluenesulfonate
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Chemsrc provides Bis-Tos-PEG6(CAS#:42749-27-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Bis-Tos-PEG6 are included as well.>> amp version: Bis-Tos-PEG6

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