Bis-PEG6-t-butyl ester

Modify Date: 2024-01-17 15:49:58

Bis-PEG6-t-butyl ester Structure
Bis-PEG6-t-butyl ester structure
Common Name Bis-PEG6-t-butyl ester
CAS Number 439114-12-2 Molecular Weight 450.56300
Density N/A Boiling Point N/A
Molecular Formula C22H42O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bis-PEG6-t-butyl ester


Bis-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate
Synonym More Synonyms

 Bis-PEG6-t-butyl ester Biological Activity

Description Bis-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C22H42O9
Molecular Weight 450.56300
Exact Mass 450.28300
PSA 98.75000
LogP 2.53300

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

MFCD18916981