Bis-PEG6-t-butyl ester

Names

[ CAS No. ]:
439114-12-2

[ Name ]:
Bis-PEG6-t-butyl ester

[Synonym ]:
MFCD18916981

Biological Activity

[Description]:

Bis-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₄₂O₉

[ Molecular Weight ]:
450.56300

[ Exact Mass ]:
450.28300

[ PSA ]:
98.75000

[ LogP ]:
2.53300

Bis-PEG6-t-butyl ester

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds