Bis-PEG6-acid

Modify Date: 2024-01-04 23:36:48

Bis-PEG6-acid Structure
Bis-PEG6-acid structure
Common Name Bis-PEG6-acid
CAS Number 119189-70-7 Molecular Weight 382.403
Density 1.2±0.1 g/cm3 Boiling Point 543.4±50.0 °C at 760 mmHg
Molecular Formula C16H30O10 Melting Point N/A
MSDS N/A Flash Point 187.7±23.6 °C

 Use of Bis-PEG6-acid


Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name Bis-PEG6-acid
Synonym More Synonyms

 Bis-PEG6-acid Biological Activity

Description Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 543.4±50.0 °C at 760 mmHg
Molecular Formula C16H30O10
Molecular Weight 382.403
Flash Point 187.7±23.6 °C
Exact Mass 382.183899
LogP -2.26
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.473

 Synonyms

4,7,10,13,16,19-Hexaoxadocosane-1,22-dioic acid
MFCD20926399