LRRK2-IN-8

Modify Date: 2025-08-30 08:38:44

LRRK2-IN-8 structure	Common Name	LRRK2-IN-8
	CAS Number	2770269-44-6	Molecular Weight	326.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂F₂N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LRRK2-IN-8

LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].

Name	LRRK2-IN-8

Description	LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Autophagy >> LRRK2 Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Neurological Disease
Target	Tyk2:10-100 nM (IC50) NUAK1:10-100 nM (IC50)
References	[1]. Jean TASSEL, et al. Kinase modulators and methods of use thereof. Patent. WO2022104206.

Molecular Formula	C₁₆H₁₂F₂N₆
Molecular Weight	326.30
InChIKey	NTLDJWYHDAANKC-UHFFFAOYSA-N
SMILES	Fc1cccc(F)c1C1=Nc2cn[nH]c2-c2cnn3c2N1CCC3

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