LRRK2-IN-8

Names

[ CAS No. ]:
2770269-44-6

[ Name ]:
LRRK2-IN-8

Biological Activity

[Description]:

LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> Autophagy >> LRRK2
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Research Areas >> Neurological Disease

[Target]

Tyk2:10-100 nM (IC50)

NUAK1:10-100 nM (IC50)


[References]

[1]. Jean TASSEL, et al. Kinase modulators and methods of use thereof. Patent. WO2022104206.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H12F2N6

[ Molecular Weight ]:
326.30

Related Compounds