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LRRK2-IN-2

Names

[ CAS No. ]:
2641059-19-8

[ Name ]:
LRRK2-IN-2

Biological Activity

[Description]:

LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of <0.6 nM. LRRK2-IN-2 can be used for the research of Parkinson's disease[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Neurological Disease

[Target]

IC50: <0.6 nM (LRRK2)[1]


[References]

[1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23Cl2F3N6O2

[ Molecular Weight ]:
543.37

Related Compounds