2204272-40-0
2204272-40-0 structure
- Name: BCL6-IN-8
- Chemical Name: BCL6-IN-8
- CAS Number: 2204272-40-0
- Molecular Formula: C30H37Cl2N5O8
- Molecular Weight: 666.553
- Create Date: 2020-01-12 19:09:32
- Modify Date: 2023-01-14 12:01:06
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BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface; shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition; BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date.
| Name | BCL6-IN-8 |
|---|
| Description | BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface; shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition; BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date. |
|---|---|
| References | References 1. Sameshima T, et al. Biochemistry. 2018 Feb 7. doi: 10.1021/acs.biochem.7b00732. View Related Products by Target Bcl-2 |
| Molecular Formula | C30H37Cl2N5O8 |
|---|---|
| Molecular Weight | 666.553 |