1973485-18-5

1973485-18-5 structure

Name: JAK1-IN-8
Chemical Name: N-(5-{4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl}imidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide
CAS Number: 1973485-18-5
Molecular Formula: C₂₂H₂₃FN₄O₃S
Molecular Weight: 442.51
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2021-12-20 12:31:13
Modify Date: 2024-01-10 18:16:12
JAK1-IN-8, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1[1].

Name	N-(5-{4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl}imidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide
Synonyms	N-(5-{4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl}imidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide MFCD30530428 Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-

Description	JAK1-IN-8, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:<500 nM (IC50) JAK2:500-1000 nM (IC50) JAK3:>5000 nM (IC50)
References	[1]. Jin Li, et al. Composés d'imidazo[1,2-a]pyridin-2-ylamine substitués, compositions pharmaceutiques et leurs méthodes d'utilisation. Patent WO2016119700A1.