LRRK2-IN-4
Modify Date: 2024-01-12 20:18:08
LRRK2-IN-4 structure
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Common Name | LRRK2-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 2641054-59-1 | Molecular Weight | 518.99 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H29ClF2N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LRRK2-IN-4LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1]. |
| Name | LRRK2-IN-4 |
|---|
| Description | LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1]. |
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| Related Catalog | |
| Target |
IC50: 2.6 nM (LRRK2)[1] |
| In Vivo | LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1]. |
| References |
| Molecular Formula | C25H29ClF2N6O2 |
|---|---|
| Molecular Weight | 518.99 |
| InChIKey | VFCYOTBJVABSBY-ZDXQCDESSA-N |
| SMILES | Cc1c(Nc2ncc3cc(Cl)c(C4CCN(C5(C)COCC5O)CC4)cc3n2)cnn1C1CC1(F)F |