HIV-1 inhibitor-29

Modify Date: 2025-09-04 17:38:34

HIV-1 inhibitor-29 Structure
HIV-1 inhibitor-29 structure
Common Name HIV-1 inhibitor-29
CAS Number 2642217-95-4 Molecular Weight 560.64
Density N/A Boiling Point N/A
Molecular Formula C30H36N6O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-29


HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS[1].

 Names

Name HIV-1 inhibitor-29

 HIV-1 inhibitor-29 Biological Activity

Description HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS[1].
Related Catalog
Target

HIV (IIIB):2.18 μM (EC50)

HIV-1 (F227L/V106A):0.974 μM (EC50)

References

[1]. Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.

 Chemical & Physical Properties

Molecular Formula C30H36N6O5
Molecular Weight 560.64
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