NH2-PEG3-C2-Boc

Modify Date: 2024-01-04 20:29:14

NH2-PEG3-C2-Boc Structure
NH2-PEG3-C2-Boc structure
Common Name NH2-PEG3-C2-Boc
CAS Number 252881-74-6 Molecular Weight 277.35700
Density N/A Boiling Point N/A
Molecular Formula C13H27NO5 Melting Point N/A
MSDS N/A Flash Point 169.7ºC

 Use of NH2-PEG3-C2-Boc


NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tert-butyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate
Synonym More Synonyms

 NH2-PEG3-C2-Boc Biological Activity

Description NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C13H27NO5
Molecular Weight 277.35700
Flash Point 169.7ºC
Exact Mass 277.18900
PSA 80.01000
LogP 1.42700

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26
HS Code 2922509090

 Synthetic Route

~%

NH2-PEG3-C2-Boc Structure

NH2-PEG3-C2-Boc

CAS#:252881-74-6

Literature: US2006/205670 A1, ; Page/Page column 105 ;

 Precursor & DownStream

Precursor  1

DownStream  1

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

H2N-OEG-CO2tBu
tert-butyl 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoate
tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate
NH2(CH2CH2O)3CH2CH2COOt-Bu
12-amino-4,7,10-trioxadodecanoic acid tert-butyl ester
Amin PEG3-t-butyl ester
tert-butyl 12-amino-4,7,10-trioxododecanoate
tert-Butyl 12-amino-4,7,10-trioxadodecanoate
3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
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