NH2-PEG3-C2-Boc

Names

[ Name ]:
NH2-PEG3-C2-Boc

[Synonym ]:
H2N-OEG-CO2tBu
tert-butyl 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoate
tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate
NH2(CH2CH2O)3CH2CH2COOt-Bu
12-amino-4,7,10-trioxadodecanoic acid tert-butyl ester
Amin PEG3-t-butyl ester
tert-butyl 12-amino-4,7,10-trioxododecanoate
tert-Butyl 12-amino-4,7,10-trioxadodecanoate
3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester

Biological Activity

[Description]:

NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₇NO₅

[ Molecular Weight ]:
277.35700

[ Flash Point ]:
169.7ºC

[ Exact Mass ]:
277.18900

[ PSA ]:
80.01000

[ LogP ]:
1.42700

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%