Bromoacetamido-PEG3-C2-Boc

Modify Date: 2024-01-14 14:38:48

Bromoacetamido-PEG3-C2-Boc Structure
Bromoacetamido-PEG3-C2-Boc structure
Common Name Bromoacetamido-PEG3-C2-Boc
CAS Number 1807537-33-2 Molecular Weight 398.290
Density 1.3±0.1 g/cm3 Boiling Point 507.6±50.0 °C at 760 mmHg
Molecular Formula C15H28BrNO6 Melting Point N/A
MSDS N/A Flash Point 260.8±30.1 °C

 Use of Bromoacetamido-PEG3-C2-Boc


Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromoacetamido-PEG3-t-Butyl Ester
Synonym More Synonyms

 Bromoacetamido-PEG3-C2-Boc Biological Activity

Description Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 507.6±50.0 °C at 760 mmHg
Molecular Formula C15H28BrNO6
Molecular Weight 398.290
Flash Point 260.8±30.1 °C
Exact Mass 397.109985
LogP 0.74
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.477

 Synonyms

2-Methyl-2-propanyl 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate
MFCD28505521
6,9,12-Trioxa-3-azapentadecan-15-oic acid, 1-bromo-2-oxo-, 1,1-dimethylethyl ester