HIV-1 inhibitor-25
Modify Date: 2024-01-17 19:28:33
HIV-1 inhibitor-25 structure
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Common Name | HIV-1 inhibitor-25 | ||
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| CAS Number | 2475658-74-1 | Molecular Weight | 433.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H19N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 inhibitor-25HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1]. |
| Name | HIV-1 inhibitor-25 |
|---|
| Description | HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1]. |
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| Related Catalog | |
| Target |
HIV (IIIB):13.6 nM (EC50) HIV-1 (L100I):1.2458 ± 0 μM (EC50) HIV-1 (K103N):0.4383 ± 0 μM (EC50) HIV-1 (Y181C):0.5075 ± 0 μM (EC50) HIV-1 (Y188L):5.8136 ± 2 μM (EC50) HIV-1 (E138K):0.1961 ± 0 μM (EC50) HIV-1 (F227L+V106A):3.0683 ± 0 μM (EC50) |
| References |
| Molecular Formula | C26H19N5O2 |
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| Molecular Weight | 433.46 |