eIF4A3 inhibitor 53a

Modify Date: 2024-01-21 16:22:07

eIF4A3 inhibitor 53a structure	Common Name	eIF4A3 inhibitor 53a
	CAS Number	2095486-67-0	Molecular Weight	588.88
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₃BrClN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of eIF4A3 inhibitor 53a

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1].

Name	eIF4A3-IN-1

Description	eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
Target	IC50: 0.2 μM (eIF4A3)[1] Kd: 0.043 μM (eIF4A3)[1]
References	[1]. Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60(8):3335-3351.

Molecular Formula	C₂₉H₂₃BrClN₅O₂
Molecular Weight	588.88

DC Chemicals Limited
China
Product Name: eIF4A3 inhibitor 53a
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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