2132392-89-1
2132392-89-1 structure
- Name: eIF4A3-IN-1q
- Chemical Name: eIF4A3-IN-1q
- CAS Number: 2132392-89-1
- Molecular Formula: C29H21BrClF3N4O3
- Molecular Weight: 645.861
- Create Date: 2020-01-12 12:37:50
- Modify Date: 2024-01-14 18:06:35
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A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM; displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM); upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM) ; shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss.
| Name | eIF4A3-IN-1q |
|---|
| Description | A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM; displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM); upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM) ; shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss. |
|---|---|
| References | References 1. Mizojiri R, et al. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082. View Related Products by Target Eukaryotic Initiation Factor (eIF) |
| Molecular Formula | C29H21BrClF3N4O3 |
|---|---|
| Molecular Weight | 645.861 |