2095677-20-4

2095677-20-4 structure

Name: eIF4A3-IN-2
Chemical Name: eIF4A3-IN-2
CAS Number: 2095677-20-4
Molecular Formula: C₂₅H₁₉Br₂ClN₄O₂
Molecular Weight: 602.70
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2019-03-03 16:59:05
Modify Date: 2024-01-10 07:10:16
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

Name	eIF4A3-IN-2

Description	eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
Target	IC50: 110 nM (eIF4A3)[1]
In Vitro	eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities[1].
References	[1]. Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.