eIF4A3-IN-13

Modify Date: 2025-08-26 18:35:07

eIF4A3-IN-13 structure	Common Name	eIF4A3-IN-13
	CAS Number	1402931-85-4	Molecular Weight	509.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₈ClNO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of eIF4A3-IN-13

eIF4A3-IN-13 (compound 75) is a silvestrol (HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translation complex with EC50s of 0.6, 15 and 0.4 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-13 can be used for the research of human cancer pathogenesis[1].

Name	eIF4A3-IN-13

Description	eIF4A3-IN-13 (compound 75) is a silvestrol (HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translation complex with EC50s of 0.6, 15 and 0.4 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-13 can be used for the research of human cancer pathogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Molecular Formula	C₂₈H₂₈ClNO₆
Molecular Weight	509.98
InChIKey	QGAOOBALZRBQLX-GWNOIRNCSA-N
SMILES	COc1ccc(C23Oc4cc(Cl)cc(OC)c4C2(O)C(O)C(C(=O)N(C)C)C3c2ccccc2)cc1

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eIF4A3-IN-13

Use of eIF4A3-IN-13

Names

eIF4A3-IN-13 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.