eIF4A3-IN-12

Modify Date: 2025-09-14 23:13:19

eIF4A3-IN-12 structure	Common Name	eIF4A3-IN-12
	CAS Number	1402931-76-3	Molecular Weight	496.94
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₅ClO₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of eIF4A3-IN-12

eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].

Name	eIF4A3-IN-12

Description	eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Molecular Formula	C₂₇H₂₅ClO₇
Molecular Weight	496.94
InChIKey	FAWAZAWGOJUXDV-PXIJUOARSA-N
SMILES	COC(=O)C1C(O)C2(O)c3c(OC)cc(Cl)cc3OC2(c2ccc(OC)cc2)C1c1ccccc1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: eIF4A3-IN-12
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Purity: 99.0%
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eIF4A3-IN-12 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.