Name | eIF4A3-IN-1 |
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Description | eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1]. |
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Related Catalog | |
Target |
IC50: 0.2 μM (eIF4A3)[1] Kd: 0.043 μM (eIF4A3)[1] |
References |
Molecular Formula | C29H23BrClN5O2 |
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Molecular Weight | 588.88 |