VU 591 hydrochloride

Modify Date: 2024-01-05 11:26:42

VU 591 hydrochloride Structure
VU 591 hydrochloride structure
Common Name VU 591 hydrochloride
CAS Number 1315380-70-1 Molecular Weight 404.76
Density N/A Boiling Point N/A
Molecular Formula C16H13ClN6O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 591 hydrochloride


VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

 Names

Name 5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)
Synonym More Synonyms

 VU 591 hydrochloride Biological Activity

Description VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].
Related Catalog
Target

IC50: 0.24 μM (ROMK)[1].

References

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

 Chemical & Physical Properties

Molecular Formula C16H13ClN6O5
Molecular Weight 404.76
Exact Mass 404.063599

 Synonyms

1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-, hydrochloride (1:1)
5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)