1783987-83-6
1783987-83-6 structure
- Name: VU 590 dihydrochloride
- Chemical Name: 7,13-Bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
- CAS Number: 1783987-83-6
- Molecular Formula: C24H32N4O7.2HCl
- Molecular Weight: 561.455
- Create Date: 2020-01-12 18:12:47
- Modify Date: 2024-02-15 17:25:00
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The first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK; also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1; induces profound, long-lasting contractions in mouse and human myometrium.
| Name | 7,13-Bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride |
|---|---|
| Synonyms |
1,4,10-Trioxa-7,13-diazacyclopentadecane, 7,13-bis[(4-nitrophenyl)methyl]-, hydrochloride (1:2)
7,13-Bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride |
| Description | The first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK; also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1; induces profound, long-lasting contractions in mouse and human myometrium. |
|---|---|
| References | References 1. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103. 2. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50. 3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74. 4. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. View Related Products by Target Potassium Channel |
| Molecular Formula | C24H32N4O7.2HCl |
|---|---|
| Molecular Weight | 561.455 |
| Exact Mass | 560.180481 |