Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecanedihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

313505-85-0

313505-85-0 structure

Name: VU590
Chemical Name: 7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane,dihydrochloride
CAS Number: 313505-85-0
Molecular Formula: C₂₄H₃₂N₄O₇
Molecular Weight: 488.53
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2016-11-04 23:31:14
Modify Date: 2025-08-25 21:21:00
VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].

Name	7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane,dihydrochloride
Synonyms	VU 590 dihydrochloride

Description	VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]
References	[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346.