1309976-62-2

1309976-62-2 structure

Name: VU 0360172 hydrochloride
Chemical Name: N-Cyclobutyl-6-[(3-fluorophenyl)ethynyl]nicotinamide hydrochlorid e (1:1)
CAS Number: 1309976-62-2
Molecular Formula: C₁₈H₁₆ClFN₂O
Molecular Weight: 330.78
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2016-11-07 15:07:27
Modify Date: 2024-04-13 20:36:50
VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

Name	N-Cyclobutyl-6-[(3-fluorophenyl)ethynyl]nicotinamide hydrochlorid e (1:1)
Synonyms	3-pyr-Cytisine

Description	VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR5:16 nM (EC50) mGluR5:195 nM (Ki)
References	[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.