VU 0360172 hydrochloride
Modify Date: 2025-08-25 08:40:35
VU 0360172 hydrochloride structure
|
Common Name | VU 0360172 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1309976-62-2 | Molecular Weight | 330.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16ClFN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU 0360172 hydrochlorideVU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. |
| Name | N-Cyclobutyl-6-[(3-fluorophenyl)ethynyl]nicotinamide hydrochlorid e (1:1) |
|---|---|
| Synonym | More Synonyms |
| Description | VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. |
|---|---|
| Related Catalog | |
| Target |
mGluR5:16 nM (EC50) mGluR5:195 nM (Ki) |
| References |
| Molecular Formula | C18H16ClFN2O |
|---|---|
| Molecular Weight | 330.78 |
| Exact Mass | 330.09400 |
| PSA | 45.48000 |
| LogP | 4.27960 |
| Storage condition | -20°C |
| 3-pyr-Cytisine |