VU 0238429
Modify Date: 2025-09-03 17:46:07
VU 0238429 structure
|
Common Name | VU 0238429 | ||
|---|---|---|---|---|
| CAS Number | 1160247-92-6 | Molecular Weight | 351.27700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12F3NO4 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of VU 0238429VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. |
| Name | 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione |
|---|---|
| Synonym | More Synonyms |
| Description | VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 1.16 μM (mAChR5)[1]. |
| In Vitro | VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1]. |
| References |
| Molecular Formula | C17H12F3NO4 |
|---|---|
| Molecular Weight | 351.27700 |
| Exact Mass | 351.07200 |
| PSA | 55.84000 |
| LogP | 3.38830 |
| InChIKey | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
| SMILES | COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc32)cc1 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H400 |
| Precautionary Statements | P273-P305 + P351 + P338 |
| RIDADR | UN 3077 9 / PGIII |
|
~10%
VU 0238429 CAS#:1160247-92-6 |
| Literature: Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione |