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VU 0238429

Names

[ CAS No. ]:
1160247-92-6

[ Name ]:
VU 0238429

[Synonym ]:
1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione

Biological Activity

[Description]:

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Others

[Target]

EC50: 1.16 μM (mAChR5)[1].


[In Vitro]

VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1].

[References]

[1]. Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.


[Related Small Molecules]

Carbachol | Darifenacin HBr | Arecoline hydrobromide | Pirenzepine, Dihydrochloride | Glycopyrrolate | Imidafenacin | Benztropine Mesylate | Xanomeline oxalate | Batefenterol | Bethanechol chloride | Cevimeline hydrochloride hemihydrate | Otilonium Bromide | solifenacin | VU0467154 | Anisodamine

Chemical & Physical Properties

[ Molecular Formula ]:
C17H12F3NO4

[ Molecular Weight ]:
351.27700

[ Exact Mass ]:
351.07200

[ PSA ]:
55.84000

[ LogP ]:
3.38830

[ Storage condition ]:
2-8℃

MSDS

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Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H400

[ Precautionary Statements ]:
P273-P305 + P351 + P338

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds