VU 590 dihydrochloride
Names
[ CAS No. ]:
1783987-83-6
[ Name ]:
VU 590 dihydrochloride
[Synonym ]:
1,4,10-Trioxa-7,13-diazacyclopentadecane, 7,13-bis[(4-nitrophenyl)methyl]-, hydrochloride (1:2)
7,13-Bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Biological Activity
[Description]:
The first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK; also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1; induces profound, long-lasting contractions in mouse and human myometrium.
[References]
References 1. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103. 2. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50. 3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74. 4. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. View Related Products by Target Potassium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C24H32N4O7.2HCl
[ Molecular Weight ]:
561.455
[ Exact Mass ]:
560.180481