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VU 0360223

Names

[ CAS No. ]:
1274859-33-4

[ Name ]:
VU 0360223

[Synonym ]:
Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-
3-Fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile

Biological Activity

[Description]:

VU 0360223 is a potent metabotropic glutamate receptors (mGluR) negative allosteric modulator with an IC50 of 61 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR:61 nM (IC50)


[References]

[1]. Pomierny-Chamioło L, et al. Metabotropic glutamatergic receptors and their ligands in drug addiction. Pharmacol Ther. 2014 Jun;142(3):281-305.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
434.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H9FN2S

[ Molecular Weight ]:
268.309

[ Flash Point ]:
216.8±25.9 °C

[ Exact Mass ]:
268.047058

[ PSA ]:
64.92000

[ LogP ]:
4.02

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.676

Related Compounds