VU 0360172 hydrochloride

Names

[ Name ]:
VU 0360172 hydrochloride

[Synonym ]:
3-pyr-Cytisine

Biological Activity

[Description]:

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR5:16 nM (EC50)

mGluR5:195 nM (Ki)

[References]

[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆ClFN₂O

[ Molecular Weight ]:
330.78

[ Exact Mass ]:
330.09400

[ PSA ]:
45.48000

[ LogP ]:
4.27960

[ Storage condition ]:
-20°C

Related Compounds

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