Name | VU 0469650 hydrochloride |
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Synonyms |
3-[(3R)-4-(Adamantan-1-ylcarbonyl)-3-methyl-1-piperazinyl]-2-pyridinecarbonitrile
2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]- 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride |
Description | VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1]. |
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Related Catalog | |
Target |
mGluR 1:99 nM (IC50) |
In Vivo | VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour[1]. VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 584.7±50.0 °C at 760 mmHg |
Molecular Formula | C22H28N4O |
Molecular Weight | 364.48 |
Flash Point | 307.4±30.1 °C |
Exact Mass | 364.226318 |
LogP | 3.17 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.624 |