VU0469650
Modify Date: 2024-04-07 15:22:48
VU0469650 structure
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Common Name | VU0469650 | ||
|---|---|---|---|---|
| CAS Number | 1443748-47-7 | Molecular Weight | 364.48 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 584.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H28N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 307.4±30.1 °C | |
Use of VU0469650VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1]. |
| Name | VU 0469650 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1]. |
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| Related Catalog | |
| Target |
mGluR 1:99 nM (IC50) |
| In Vivo | VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour[1]. VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.7±50.0 °C at 760 mmHg |
| Molecular Formula | C22H28N4O |
| Molecular Weight | 364.48 |
| Flash Point | 307.4±30.1 °C |
| Exact Mass | 364.226318 |
| LogP | 3.17 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.624 |
| 3-[(3R)-4-(Adamantan-1-ylcarbonyl)-3-methyl-1-piperazinyl]-2-pyridinecarbonitrile |
| 2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]- |
| 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride |