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VU 591 hydrochloride

Names

[ CAS No. ]:
1315380-70-1

[ Name ]:
VU 591 hydrochloride

[Synonym ]:
1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-, hydrochloride (1:1)
5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)

Biological Activity

[Description]:

VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.24 μM (ROMK)[1].


[References]

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13ClN6O5

[ Molecular Weight ]:
404.76

[ Exact Mass ]:
404.063599

Related Compounds