VU 591 hydrochloride

Names

[ Name ]:
VU 591 hydrochloride

[Synonym ]:
1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-, hydrochloride (1:1)
5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)

Biological Activity

[Description]:

VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.24 μM (ROMK)[1].

[References]

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₃ClN₆O₅

[ Molecular Weight ]:
404.76

[ Exact Mass ]:
404.063599

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.