fumaric acid

Modify Date: 2025-08-20 13:38:12

fumaric acid structure	Common Name	fumaric acid
	CAS Number	110-17-8	Molecular Weight	116.072
	Density	1.5±0.1 g/cm3	Boiling Point	355.5±25.0 °C at 760 mmHg
	Molecular Formula	C₄H₄O₄	Melting Point	298-300 °C (subl.)(lit.)
	MSDS	Chinese USA	Flash Point	183.0±19.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of fumaric acid

Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.

Name	fumaric acid
Synonym	More Synonyms

Description	Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Cancer Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Density	1.5±0.1 g/cm3
Boiling Point	355.5±25.0 °C at 760 mmHg
Melting Point	298-300 °C (subl.)(lit.)
Molecular Formula	C₄H₄O₄
Molecular Weight	116.072
Flash Point	183.0±19.7 °C
Exact Mass	116.010956
PSA	74.60000
LogP	-0.01
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.526
Stability	Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
Water Solubility	0.63 g/100 mL (25 ºC)

fumaric acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LS9625000

CHEMICAL NAME :: Fumaric acid

CAS REGISTRY NUMBER :: 110-17-8

BEILSTEIN REFERENCE NO. :: 0605763

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H4-O4

MOLECULAR WEIGHT :: 116.08

WISWESSER LINE NOTATION :: QV1U1VQ -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 587 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 77,750,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33940 No. of Facilities: 2317 (estimated) No. of Industries: 27 No. of Occupations: 44 No. of Employees: 30637 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33940 No. of Facilities: 5692 (estimated) No. of Industries: 40 No. of Occupations: 58 No. of Employees: 136448 (estimated) No. of Female Employees: 48919 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36
Safety Phrases	S26
RIDADR	UN 9126
WGK Germany	1
RTECS	LS9625000
HS Code	2942000000

Precursor 10
CAS#:98-01-1 Furfural CAS#:88-14-2 Furan-2-carboxy... CAS#:67-47-0 5-hydroxymethyl... CAS#:70-55-3 4-Toluenesulfonamide
CAS#:623-91-6 Diethyl fumarate CAS#:608-36-6 meso-2,3-Dibrom... CAS#:80513-23-1 (R)-4,4,4-trich... CAS#:617-48-1 (±)-Malic Acid
CAS#:624-49-7 Dimethyl fumarate CAS#:107-93-7 Crotonic acid
DownStream 10
CAS#:608-36-6 meso-2,3-Dibrom... CAS#:1114-00-7 (±)-2,3-Dibromo... CAS#:328-42-7 Oxaloacetic acid CAS#:110-15-6 Succinic acid
CAS#:4226-18-0 UNII:EU52DFC4WJ CAS#:325145-35-5 (S)-1-N-Boc-2-e... CAS#:34675-24-6 bis(5-methyl-2-... CAS#:3813-52-3 Nadic acid
CAS#:3878-55-5 4-Methoxy-4-oxo... CAS#:106-65-0 Dimethyl succinate

HS Code	2942000000

A metabolic-based approach to improve xylose utilization for fumaric acid production from acid pretreated wheat bran by Rhizopus oryzae.

Bioresour. Technol. 180 , 119-27, (2015)

In this work, wheat bran (WB) was utilized as feedstock to synthesize fumaric acid by Rhizopus oryzae. Firstly, the pretreatment process of WB by dilute sulfuric acid hydrolysis undertaken at 100°C fo...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

U-1149

FEMA 2488

FUMARSAEURE

but-2-en-1,4-dioic acid

TMEDA

trans-2-Butenedioic Acid

Fumarsure

trans-butenedioic acid

Fumaric acid

fumaric

EINECS 203-743-0

MFCD00002700

Boletic acid

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fumaric acid

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