Succinic acid

Modify Date: 2024-01-01 19:53:48

Succinic acid Structure
Succinic acid structure
Common Name Succinic acid
CAS Number 110-15-6 Molecular Weight 118.088
Density 1.4±0.1 g/cm3 Boiling Point 236.1±13.0 °C at 760 mmHg
Molecular Formula C4H6O4 Melting Point 185 °C
MSDS Chinese USA Flash Point 110.9±16.3 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of Succinic acid


Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

 Names

Name succinic acid
Synonym More Synonyms

 Succinic acid Biological Activity

Description Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 236.1±13.0 °C at 760 mmHg
Melting Point 185 °C
Molecular Formula C4H6O4
Molecular Weight 118.088
Flash Point 110.9±16.3 °C
Exact Mass 118.026611
PSA 74.60000
LogP -0.59
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.478
Storage condition Store at RT.
Stability Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.
Water Solubility 80 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM4900000
CHEMICAL NAME :
Succinic acid
CAS REGISTRY NUMBER :
110-15-6
BEILSTEIN REFERENCE NO. :
1754069
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H6-O4
MOLECULAR WEIGHT :
118.10
WISWESSER LINE NOTATION :
QV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2702 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Fibroblast
DOSE/DURATION :
20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84381 No. of Facilities: 316 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 3351 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84381 No. of Facilities: 1652 (estimated) No. of Industries: 16 No. of Occupations: 38 No. of Employees: 31198 (estimated) No. of Female Employees: 16182 (estimated)

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39-S37/39
RIDADR UN 3265 8/PG 3
WGK Germany 1
RTECS WM4900000
Hazard Class 8.0
HS Code 2917190090

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles173

More Articles
Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Direct silylation of Trypanosoma brucei metabolites in aqueous samples and their GC-MS/MS analysis.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 967 , 134-8, (2014)

A simple two-step method for the derivatization of polar compounds (lactate, alanine, glycerol, succinate and glucose) using hexamethyldisilazane (HMDS) and N,O-bis(trimethylsilyl)trifluoroacetamide (...

Lactic acid production from acidogenic fermentation of fruit and vegetable wastes.

Bioresour. Technol. 191 , 53-8, (2015)

This work focused on the lactic acid production from acidogenic fermentation of fruit and vegetable wastes treatment. A long term completely stirred tank reactor (CSTR) lasting for 50 days was operate...

 Synonyms

MFCD00002789
Butane diacid
Butanedioic acid,natural
HOOC-CH2-CH2-COOH
4-02-00-01908 (Beilstein Handbook Reference)
Bernsteinsaure [German]
Succinic acid
1,4-Butanedioic acid
1,2-Ethanedicarboxylic acid
Sal succini
QV2VQ
Succinic acid
Butanedioic acid
Asuccin
Katasuccin
Wormwood
EINECS 203-740-4
spirit of amber
AMBER ACID
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