Maleic acid

Modify Date: 2024-01-02 19:20:40

Maleic acid structure	Common Name	Maleic acid
	CAS Number	110-16-7	Molecular Weight	116.072
	Density	1.5±0.1 g/cm3	Boiling Point	355.5±25.0 °C at 760 mmHg
	Molecular Formula	C₄H₄O₄	Melting Point	134-138ºC
	MSDS	Chinese USA	Flash Point	183.0±19.7 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Maleic acid

Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.

Name	maleic acid
Synonym	More Synonyms

Description	Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Infection
Target	Human Endogenous Metabolite GAD
In Vitro	The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal[2].
References	[1]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9. [2]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms; Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb;69:96-104.

Density	1.5±0.1 g/cm3
Boiling Point	355.5±25.0 °C at 760 mmHg
Melting Point	134-138ºC
Molecular Formula	C₄H₄O₄
Molecular Weight	116.072
Flash Point	183.0±19.7 °C
Exact Mass	116.010956
PSA	74.60000
LogP	-0.01
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.526
Storage condition	Store at RT.
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, bases.
Water Solubility	790 g/L (25 ºC)

Maleic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OM9625000

CHEMICAL NAME :: Maleic acid

CAS REGISTRY NUMBER :: 110-16-7

BEILSTEIN REFERENCE NO. :: 0605762

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C4-H4-O4

MOLECULAR WEIGHT :: 116.08

WISWESSER LINE NOTATION :: QV1U1VQ -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 708 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >720 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1560 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 20 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84505 No. of Facilities: 1840 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 17036 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84505 No. of Facilities: 2076 (estimated) No. of Industries: 36 No. of Occupations: 45 No. of Employees: 30064 (estimated) No. of Female Employees: 11590 (estimated)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302 + H312-H315-H317-H318-H335
Precautionary Statements	P280-P301 + P312 + P330-P305 + P351 + P338 + P310
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S28-S37
RIDADR	UN 2215
WGK Germany	1
RTECS	OM9625000
Packaging Group	III
HS Code	2917190090

Precursor 0
DownStream 10
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HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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(2Z)-2-Butenedioic acid

2-Butenedioic acid, (2Z)-

cis-2-Butenedioic Acid

2-Butenedioicacid (2Z)-

MFCD00063177

EINECS 203-742-5

Maleic acid

cis-Butenedioic acid,Toxilic acid

Maleic acid [NA2215]

(2Z)-But-2-enedioic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Maleic acid
Price: ￥78.0/20mg ￥58.0/500g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Maleic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Maleic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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Maleic acid

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