Furan-2-carboxylic acid

Modify Date: 2025-08-20 12:50:48

Furan-2-carboxylic acid structure	Common Name	Furan-2-carboxylic acid
	CAS Number	88-14-2	Molecular Weight	112.084
	Density	1.3±0.1 g/cm3	Boiling Point	230-232 ºC
	Molecular Formula	C₅H₄O₃	Melting Point	129-133 ºC
	MSDS	Chinese USA	Flash Point	137 ºC
	Symbol	GHS07	Signal Word	Warning

Use of Furan-2-carboxylic acid

2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[1]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[2].

Name	2-furoic acid
Synonym	More Synonyms

Description	2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[1]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Research Areas >> Metabolic Disease
In Vivo	2-Furoic acid significantly reduces serum cholesterol and serum triglyceride levels[2]. 2-Furoic acid also lowers the liver and small intestine ATP dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase and heparin induced lipoprotein lipase activities[2]. 2-Furoic acid shows the LD50 of 250 mg/kg i.p. in the acute toxicity studies in mice[2].
References	[1]. Wordofa GG, et al. Tolerance and metabolic response of Pseudomonas taiwanensis VLB120 towards biomass hydrolysate-derived inhibitors. Biotechnol Biofuels. 2018 Jul 19;11:199. [2]. Hall IH, et al. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23.

Density	1.3±0.1 g/cm3
Boiling Point	230-232 ºC
Melting Point	129-133 ºC
Molecular Formula	C₅H₄O₃
Molecular Weight	112.084
Flash Point	137 ºC
Exact Mass	112.016045
PSA	50.44000
LogP	0.64
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.513
Water Solubility	36 g/L (20 ºC)

Furan-2-carboxylic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1763000

CHEMICAL NAME :: 2-Furoic acid

CAS REGISTRY NUMBER :: 88-14-2

BEILSTEIN REFERENCE NO. :: 0110149

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H4-O3

MOLECULAR WEIGHT :: 112.09

WISWESSER LINE NOTATION :: T5OJ BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1977 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 774 (estimated) No. of Female Employees: 10 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C;Xi
Risk Phrases	R34;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S36
RIDADR	UN 3265 8/PG 2
WGK Germany	3
RTECS	LV1763000
HS Code	29321900

Precursor 10
CAS#:98-00-0 Furfuryl alcohol CAS#:552-86-3 2,2'-Furoin CAS#:98-01-1 Furfural CAS#:584-12-3 2-Bromofuran
CAS#:201230-82-2 carbon monoxide CAS#:110-00-9 Furan CAS#:124-38-9 Carbon dioxide CAS#:611-13-2 Methyl 2-furoate
CAS#:2434-03-9 2,3-Dibromofura... CAS#:1192-62-7 1-(Furan-2-yl)e...
DownStream 10
CAS#:109930-25-8 Furfuryl Alcohol-d2 CAS#:380889-69-0 5-(4-fluorophen... CAS#:1917-15-3 5-Methyl-2-furo... CAS#:4412-96-8 3-Methyl-2-furo...
CAS#:40172-95-0 1-(2-furoyl)pip... CAS#:31350-27-3 Piperazine, 1,4... CAS#:4412-91-3 3-Furancarbinol CAS#:54829-48-0 2-IODOFURAN (ST...
CAS#:615-10-1 2-Furancarboxyl... CAS#:41019-43-6 5-(2-chlorophen...

HS Code	2932190090
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Optimization and Kinetic Studies on Biodiesel Production from Kusum (Schleichera triguga) Oil Using Response Surface Methodology.

J. Oleo Sci. 64 , 987-97, (2015)

In the present study, the low-cost non-edible kusum (Schleichera triguga) oil with a substantial amount of free fatty acid (FFA) was utilized for biodiesel synthesis. In pretreatment step, FFA was red...

High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue.

Biotechnol. Bioeng. 112 , 1770-82, (2015)

Corncob residue as the lignocellulosic biomass accumulated phenolic compounds generated from xylitol production industry. For utilization of this biomass, Zymomonas mobilis ZM4 was tested as the ethan...

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China
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